An Atlas of Conserved Transcription Factor Binding Sites Reveals the Cell Type-Resolved Gene Regulatory Landscape of Flowering Plants

Understanding the gene regulatory mechanisms that govern plant development requires precise, cell-type-resolved insights into transcription factor binding. In this study, we present a comprehensive atlas of conserved transcription factor binding sites across diverse flowering plant species. Using single-cell and spatial transcriptomics, we mapped the gene regulatory networks at an unprecedented resolution, revealing key transcriptional programs that define cell identities. Our findings provide a foundational resource for investigating conserved and species-specific gene regulation, with implications for plant development, stress response, and crop engineering.

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